Post vaccination syndrome introduction for practitioners

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Post vaccination syndrome refers to the constellation of symptoms experienced by sufferers following vaccination.

  • The most common symptoms include fatigue, "brain fog", parathesia, dizzines, and heart issues.
  • Most experience multiple symptoms.
  • The range of symptoms is extremely diverse. The patient population is highly heterogenous in the combination of symptoms that they experience.
  • There may be a relapse/remitting pattern to the severity of symptoms.
  • Some/many patients develop new symptoms after the initial onset of post vaccination syndrome.
  • For many but not all patients, symptoms dramatically reduce after several months.

Treating these patients can be a challenge because the syndrome is new, there are no established treatments, and the symptoms may be non-specific.

React19 has survey data that covers the various symptoms that patients experience. See https://www.react19.org/post/persistent-neurological-symptoms-patient-survey and click 'download PDF'

Similarities between long COVID (PASC) and post vaccination syndrome

Symptoms overlap heavily between post vaccination syndrome and long COVID / post-acute sequelae of COVID-19 (PASC). Patients respond similarly to the same treatments. Because of these similarities, many refer to both patient groups as "long haulers". Both syndromes likely share a common root cause: S1 spike protein. See the etiology page for an overview of the various theories that currently exist.

Biomarkers exist

There are two sets of tests that seem to have high specificity and sensitivity for post vaccination syndrome:

  • An inflammatory marker panel developed by IncellDX has found unusual levels of various cytokines in post vaccination patients. These include IFN-γ (interferon gamma), IL-2 (interluekin-2), and CCL4-MIP-1β. The details of this test is described in the paper Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning (https://doi.org/10.3389/fimmu.2021.700782).
  • Auto-antibody tests offered by the German lab Cell-Trend seem to find elevated auto-antibody levels in long COVID patients. A paper by Wallukat et al. provides data on long COVID patients versus controls (see https://doi.org/10.1016/j.jtauto.2021.100100).

Other biomarkers:

Conventional medical testing often finds nothing

Common comorbidities that can be diagnosed and/or treated

Long haulers have elevated rates of certain conditions that can be objectively diagnosed without relying only on self-reporting by patients.

Heart conditions

  • Arrhythmias
  • Pericarditis, myocarditis

Autoimmune conditions

Long haulers exhibit much higher rates of auto-antibodies than healthy controls.


Other conditions that can be diagnosed and/or treated

Neurological symptoms

For neurological symptoms such as poor concentration, forgetfulness, and mood disturbance, some patients seem to respond to SSRIs such as fluvoxamine. Please refer to the FLCCC i RECOVER protocol for more information. https://covid19criticalcare.com/covid-19-protocols/i-recover-protocol/


Note that these lists are not exhaustive.

Differential diagnosis

Post vaccination syndrome has symptoms that overlap with the following illnesses:

  • Breast implant illness / silicone implant incompatibility syndrome / and ASIA (autoimmune/inflammatory syndrome induced by adjuvants).
  • Chronic Lyme (“PTLDS”).
  • ME/CFS.
  • Gulf War syndrome, which affects the participants of the 1991 Gulf war.
  • HPV vaccine injury.
  • Post viral syndromes from SARS1, MERS, Ebola, etc.
  • Long COVID / PASC.

Post vaccination syndrome also shares a few symptoms with thyroid disorders, so thyroid testing may be warranted.

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