Megan weitner's 2016 thesis

Mechanisms of action

Membrane permeability or homeostasis mechanisms:

• Hydroxychloroquine: As a base, it alters the intracellular pH by attracting acids. This may disurpt the ion transport gradient, preventing cells from acquiring the necessary nutrients in their dormant state. When combined with drugs that act on DNA transcription, activity from transmembrane proteins may also be affected, further preventing the cells from maintaining their necessary nutrient and ion balance.
• Fluconazole:

Free radical producing:

• Methylene blue:
• Artemisinin:

Protein synthesis inhibitor:

• Doxycycline:
• Azithromycin:
• Nitrofurantoin:

DNA transcription:

• Rifabutin: