Megan weitner's 2016 thesis: Difference between revisions
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(Created page with "== Mechanisms of action == * '''Hydroxychloroquine''': As a base, it alters the intracellular pH by attracting acids. This may disurpt the ion transport gradient, preventing cells from acquiring the necessary nutrients in their dormant state. When combined with drugs that act on DNA transcription, activity from transmembrane proteins may also be affected, further preventing the cells from maintaining their necessary nutrient and ion balance.") |
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== Mechanisms of action == | == Mechanisms of action == | ||
Membrane permeability or homeostasis mechanisms: | |||
* '''Hydroxychloroquine''': As a base, it alters the intracellular pH by attracting acids. This may disurpt the ion transport gradient, preventing cells from acquiring the necessary nutrients in their dormant state. When combined with drugs that act on DNA transcription, activity from transmembrane proteins may also be affected, further preventing the cells from maintaining their necessary nutrient and ion balance. | * '''Hydroxychloroquine''': As a base, it alters the intracellular pH by attracting acids. This may disurpt the ion transport gradient, preventing cells from acquiring the necessary nutrients in their dormant state. When combined with drugs that act on DNA transcription, activity from transmembrane proteins may also be affected, further preventing the cells from maintaining their necessary nutrient and ion balance. | ||
* '''Fluconazole''': | |||
Free radical producing: | |||
* '''Methylene blue''': | |||
* '''Artemisinin''': | |||
Protein synthesis inhibitor: | |||
* '''Doxycycline''': | |||
* '''Azithromycin''': | |||
* '''Nitrofurantoin''': | |||
DNA transcription: | |||
* '''Rifabutin''': | |||
Revision as of 18:55, 26 May 2022
Mechanisms of action
Membrane permeability or homeostasis mechanisms:
- Hydroxychloroquine: As a base, it alters the intracellular pH by attracting acids. This may disurpt the ion transport gradient, preventing cells from acquiring the necessary nutrients in their dormant state. When combined with drugs that act on DNA transcription, activity from transmembrane proteins may also be affected, further preventing the cells from maintaining their necessary nutrient and ion balance.
- Fluconazole:
Free radical producing:
- Methylene blue:
- Artemisinin:
Protein synthesis inhibitor:
- Doxycycline:
- Azithromycin:
- Nitrofurantoin:
DNA transcription:
- Rifabutin: