Multiple persistent infections: Difference between revisions
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== The healthy human virome == | == The healthy human virome == | ||
Kumata and colleagues published the paper ''A tissue level atlas of the healthy human virome'' (https://doi.org/10.1186/s12915-020-00785-5). Their study examined the various viruses that live inside health human beings. One of their findings was that viruses don't always live in the same places in the body. One person might have Epstein-Barr virus (EBV) living only in their spleen while another person might have EBV living in multiple organs. The virus is usually unable to establish itself in the blood. | |||
[[File:Healthy human virome figure 2.png|550px]] | |||
One phenomenon seen in a few long haulers are reactivated infections. Pre-existing viruses such as EBV, shingles / herpes zoster / varicella-zoster virus, etc. turn into more active infections and can be detected in the blood using commercially available tests. This suggests that the immune system is dysfunctional and unable to suppress persistent infections like a healthy immune system would. | |||
== Successive infection == | == Successive infection == | ||
Revision as of 23:43, 4 March 2022
What's old is new again. Long haul syndromes (long COVID and vaccine injury) can be thought of as remixes of health problems that have previously existed. The syndromes heavily overlap with health conditions that have existed in the past.
ME/CFS versus post vaccination syndrome symptoms are compared below:
Data from:
- https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2429637/pdf/postmedj00163-0031.pdf
- https://www.react19.org/post/persistent-neurological-symptoms-patient-survey
Breast implant illness versus post vaccination are compared below:
Data from:
- https://www.fda.gov/medical-devices/breast-implants/medical-device-reports-systemic-symptoms-women-breast-implants
- https://www.react19.org/post/persistent-neurological-symptoms-patient-survey
The common denominator
One common thread that runs through long haul, ME/CFS, and breast implant illness (BII) are infectious diseases. Breast implants, while being inorganic and biologically inactive, turn out to be an excellent environment for bacteria. One observational study on BII patients found that BII patients were six times more likely to have culturable bacteria or fungi/yeast growing on their implants compared to healthy controls. Limitations on our current ability to detect microorganisms in biofilm structures may mean that bacterial colonies are more common than what the study detected (36% among BII patients).
ME/CFS is also a condition that has been linked to infectious diseases:
- Various infectious diseases: enteroviruses, herpesviruses including Epstein-Barr virus, Q fever, coxsackie b, and Ross River virus.
- Outbreaks
- Stress, e.g. from a divorce. Stress is thought to weaken the immune system.
- Trauma, e.g. a car accident, head injury, etc.
The data suggests that many different paths can lead to the body being unable to control persistent infections. The diversity of the bacteria, viruses, yeast, parasites, etc. that live inside humans would explain why symptoms vary so much from patient to patient.
The healthy human virome
Kumata and colleagues published the paper A tissue level atlas of the healthy human virome (https://doi.org/10.1186/s12915-020-00785-5). Their study examined the various viruses that live inside health human beings. One of their findings was that viruses don't always live in the same places in the body. One person might have Epstein-Barr virus (EBV) living only in their spleen while another person might have EBV living in multiple organs. The virus is usually unable to establish itself in the blood.
One phenomenon seen in a few long haulers are reactivated infections. Pre-existing viruses such as EBV, shingles / herpes zoster / varicella-zoster virus, etc. turn into more active infections and can be detected in the blood using commercially available tests. This suggests that the immune system is dysfunctional and unable to suppress persistent infections like a healthy immune system would.