User:User123: Difference between revisions

Latest revision as of 03:52, 10 April 2023

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 [[Other_treatments]]
-== Super antigen theory notes ==
+== Superantigen theory notes ==
-https://sci-hub.se/https://doi.org/10.1016/0882-4010(87)90003-9 - In the TMEV virus, inbred mice can be susceptible or resistant to the virus.
+[[Spike_as_a_superantigen|SARS-CoV-2 spike as a superantigen]]
-https://www.nature.com/articles/s41422-021-00495-9 - SARS COV 2 spike protein activates TLR4 and acts as a superantigen
-=== TLR4 ===
-https://pubmed.ncbi.nlm.nih.gov/18203139/ - !!! The TLR4 pathway seems to regulate the priming of Th17 cells and reduce the severity of EAE.
-https://pubmed.ncbi.nlm.nih.gov/19211042/ - "TLR4 down regulates disease severity in EAE and Th17 cell responses"
-https://pubmed.ncbi.nlm.nih.gov/21685327/ - This study had conflicting results.  TLR4 knockout mice had the same susceptibility to disease.
-https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1375233/ - TLR4 ligands include LPS, Taxol
-https://jitc.biomedcentral.com/articles/10.1186/s40425-019-0625-x - LPS is used to treat cancer as a TLR4 ligand / vaccine adjuvant.