Delayed onset of vaccine injury

Some evidence suggests that COVID vaccines can lead to delayed and serious reactions weeks after initial vaccination. There are a few case reports of symptom onset 10 weeks after vaccination.

MIS-V

Multisystem Inflammatory Syndrome (MIS) is labelled as MIS-C when it develops in children following a COVID-19 infection. In rare cases, it can develop in adults (MIS-A). Various published case reports have noted that it can also develop after vaccination (MIS-V) without a prior COVID-19 infection. Onset of MIS-V can be many weeks after initial exposure.

Symptoms of MIS-C/A/V are similar to Kawasaki disease.

Published case reports on MIS-V

• Nune et al. - 2 days to onset, 44 year old female. "we highlight the first reported MIS-V case after the SARS-CoV-2 vaccine"
• Choi et al. - 10 days to onset, 22 year old female. "Ten days after receiving the first dose of coronavirus disease vaccine, a 22-year-old woman in South Korea experienced myocarditis, myopathy, pericarditis, and gastroenteritis; rash subsequently developed."
• Grome et al. - 22 days to onset, male healthcare worker in his 30s. "a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination."
• Salzman et al. - Onset not clear, 20 year old female, vaccinated 15 days before hospital admission.
• Buchhorn et al. - Onset 10 weeks after vaccination, 18 year old male.
• Yalçinkaya et al. - Diagnosis 27 days after vaccination, 12 year old male.
• Abdelgalil et al. - Onset ~5 weeks after Moderna vaccination, 12 year old male.
• Kahn et al. - Symptom onset began 2 hours after vaccine administration, 20 year old male.
• Lieu et al. - Onset 10 days after vaccination, 21 year old female.
• Bishawi et al. - Onset 10 days after second vaccine, 37 year old female.
• DeJong et al. - 14 year old female.
• Chai et al. - Onset 5 days after vaccination, 17 year old male.
• Park et al.- Onset 6 days after ChAdOx1 vaccination, 67 year old male.
• Stappers et al. - Presented symptoms 18 days after Oxford/AstraZeneca vaccine, young woman.

Selected VAERS case reports

• 2006451 - 12 days to onset, 6 year old female diagnosed with Kawasaki disease.
• 1998916 - 27 days to onset, 9 year old female diagnosed with Kawasaki disease. "5 days after covid-19 pfizer vaccine was given she developed a fever with a mild rash on her extremities. [...] Rash progressed to what appeared to be erythema multiforme, she had conjunctivitis as well as persistent fevers. Ended up being sent to ED on 12/31/21 for leukocytosis and thrombocytopenia [...]"
• 2006451 - 12 days to onset, 6 year old female who was diagnosed with Kawasaki disease. Vaccinated on 12-11-2021, developed rash 12/23.
• 2175151 - 2 days to onset, 15 year old male diagnosed with Kawasaki's disease.
• 2194347 - 69 days to onset, 5 year old female diagnosed with MIS-C. History of Kawasaki disease X2, 2018/2020.
• 2226084 - Kawasaki disease following COVID, vaccination was 266 days ago.
• 2271220 - 54 days to onset, 10 year old male with "MIS-C vs Kawasaki".
• 2271233 - 39 days to onset, 10 year old male. "Constellation of symptoms is concerning for Kawasaki versus MIS-C."
• 2137230 - 43 days to onset, 7 year old male being treated for MIS-C.

Repeated exposure to spike protein

Many observational studies show that prior vaccination and COVID-19 infections increase the risk of adverse events following subsequent spike protein exposure. This suggests that spike protein exposure can cause a long-term vulnerability to spike protein exposure without causing immediately obvious symptoms. A future vaccine injury or case of Long COVID could be considered to be a delayed side effect of spike protein exposure.

See the studies section on the COVID prevention and treatment page.

Patient survey data

• React19's survey #1 (Persistent Symptoms Survey) found a minimal number of surveyees reporting that their symptoms began post 2 weeks following vaccination. The survey population may have been skewed by low awareness of vaccine injury, causing those with delayed onset to not view themselves as vaccine injured.
• A German vaccine injury group's survey found that 21.2% of surveyees reported symptoms developing more than 2 weeks after vaccination. An English translation of the survey will be published in the future.