Delayed onset of vaccine injury: Difference between revisions

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(some case reports)
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* '''[https://doi.org/10.3201/eid2711.211612 Grome et al.] - 22 days to onset''', male healthcare worker in his 30s.  "a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination."
* '''[https://doi.org/10.3201/eid2711.211612 Grome et al.] - 22 days to onset''', male healthcare worker in his 30s.  "a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination."
* [https://doi.org/10.3201%2Feid2707.210594 Salzman et al.] - Onset not clear, 20 year old female, vaccinated 15 days before hospital admission.
* [https://doi.org/10.3201%2Feid2707.210594 Salzman et al.] - Onset not clear, 20 year old female, vaccinated 15 days before hospital admission.
* '''[https://doi.org/10.3390/vaccines9111353 Buchhorn et al.] - Onset 10 weeks after vaccination''', 18 year old male.
* '''[https://doi.org/10.3390/vaccines9111353 Buchhorn et al.] - Onset 10 weeks after vaccination''', 18 year old male.
* '''[https://doi.org/10.1097/inf.0000000000003432 Yalçinkaya et al.] - Diagnosis 27 days after vaccination''', 12 year old male.
* '''[https://doi.org/10.1097/inf.0000000000003442 Abdelgalil et al.] - Onset ~5 weeks after Moderna vaccination''', 12 year old male.
* [https://doi.org/10.1097/cce.0000000000000578 Kahn et al.] - Symptom onset began 2 hours after vaccine administration, 20 year old male.
* [https://doi.org/10.1016/j.ijid.2021.12.339 Lieu et al.] - Onset 10 days after vaccination, 21 year old female.
* [https://doi.org/10.1002/ccr3.5138 Bishawi et al.] - Onset 10 days after second vaccine, 37 year old female.
* [https://doi.org/10.1097/inf.0000000000003444 DeJong et al.] - 14 year old female.
* [https://doi.org/10.1111/apa.16141 Chai et al.] - Onset 5 days after vaccination, 17 year old male.
* [https://doi.org/10.3346/jkms.2021.36.e312 Park et al.]- Onset 6 days after ChAdOx1 vaccination, 67 year old male.


===Selected VAERS case reports===
===Selected VAERS case reports===

Revision as of 15:28, 7 August 2022

Some evidence suggests that COVID vaccines can lead to delayed and serious reactions weeks after initial vaccination. Some case reports indicate onset 10 weeks after vaccination.

MIS-V

Multisystem Inflammatory Syndrome (MIS) is labelled as MIS-C when it develops in children following a COVID-19 infection. In rare cases, it can develop in adults (MIS-A). Various published case reports have noted that it can also develop after vaccination (MIS-V) without any evidence of a prior COVID-19 infection. Onset of MIS-V can be weeks after initial infection.

Symptoms of MIS-C/A/V are similar to Kawasaki disease.

Published case reports on MIS-V

  • Nune et al. - 2 days to onset, 44 year old female. "we highlight the first reported MIS-V case after the SARS-CoV-2 vaccine"
  • Choi et al. - 10 days to onset, 22 year old female. "Ten days after receiving the first dose of coronavirus disease vaccine, a 22-year-old woman in South Korea experienced myocarditis, myopathy, pericarditis, and gastroenteritis; rash subsequently developed."
  • Grome et al. - 22 days to onset, male healthcare worker in his 30s. "a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination."
  • Salzman et al. - Onset not clear, 20 year old female, vaccinated 15 days before hospital admission.
  • Buchhorn et al. - Onset 10 weeks after vaccination, 18 year old male.
  • Yalçinkaya et al. - Diagnosis 27 days after vaccination, 12 year old male.
  • Abdelgalil et al. - Onset ~5 weeks after Moderna vaccination, 12 year old male.
  • Kahn et al. - Symptom onset began 2 hours after vaccine administration, 20 year old male.
  • Lieu et al. - Onset 10 days after vaccination, 21 year old female.
  • Bishawi et al. - Onset 10 days after second vaccine, 37 year old female.
  • DeJong et al. - 14 year old female.
  • Chai et al. - Onset 5 days after vaccination, 17 year old male.
  • Park et al.- Onset 6 days after ChAdOx1 vaccination, 67 year old male.

Selected VAERS case reports

  • 2006451 - 12 days to onset, 6 year old female diagnosed with Kawasaki disease.
  • 1998916 - 27 days to onset, 9 year old female diagnosed with Kawasaki disease. "5 days after covid-19 pfizer vaccine was given she developed a fever with a mild rash on her extremities. [...] Rash progressed to what appeared to be erythema multiforme, she had conjunctivitis as well as persistent fevers. Ended up being sent to ED on 12/31/21 for leukocytosis and thrombocytopenia [...]"
  • 2006451 - 12 days to onset, 6 year old female who was diagnosed with Kawasaki disease. Vaccinated on 12-11-2021, developed rash 12/23.
  • 2175151 - 2 days to onset, 15 year old male diagnosed with Kawasaki's disease.
  • 2194347 - 69 days to onset, 5 year old female diagnosed with MIS-C. History of Kawasaki disease X2, 2018/2020.
  • 2226084 - Kawasaki disease following COVID, vaccination was 266 days ago.
  • 2271220 - 54 days to onset, 10 year old male with "MIS-C vs Kawasaki".
  • 2271233 - 39 days to onset, 10 year old male. "Constellation of symptoms is concerning for Kawasaki versus MIS-C."
  • 2137230 - 43 days to onset, 7 year old male being treated for MIS-C.
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