Delayed onset of vaccine injury: Difference between revisions

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Some evidence suggests that COVID vaccines can lead to delayed and serious reactions weeks after initial vaccination.
Some evidence suggests that COVID vaccines can lead to delayed and serious reactions weeks after initial vaccination.  Some case reports indicate onset 10 weeks after vaccination.


== MIS-V ==
== MIS-V ==
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Symptoms of MIS-C/A/V are similar to Kawasaki disease.
Symptoms of MIS-C/A/V are similar to Kawasaki disease.
=== Published case reports on MIS-V ===
* [https://casereports.bmj.com/content/14/7/e243888 Nune et al.] - 2 days to onset, 44 year old female.  "we highlight the first reported MIS-V case after the SARS-CoV-2 vaccine"
* [https://doi.org/10.3201/eid2802.211938 Choi et al.] - 10 days to onset, 22 year old female.  "Ten days after receiving the first dose of coronavirus disease vaccine, a 22-year-old woman in South Korea experienced myocarditis, myopathy, pericarditis, and gastroenteritis; rash subsequently developed."
* '''[https://doi.org/10.3201/eid2711.211612 Grome et al.] - 22 days to onset''', male healthcare worker in his 30s.  "a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination."
* [https://doi.org/10.3201%2Feid2707.210594 Salzman et al.] - Onset not clear, 20 year old female, vaccinated 15 days before hospital admission.
* '''[https://doi.org/10.3390/vaccines9111353 Buchhorn et al.] - Onset 10 weeks after vaccination''', 18 year old male. 


===Selected VAERS case reports===
===Selected VAERS case reports===

Revision as of 14:49, 7 August 2022

Some evidence suggests that COVID vaccines can lead to delayed and serious reactions weeks after initial vaccination. Some case reports indicate onset 10 weeks after vaccination.

MIS-V

Multisystem Inflammatory Syndrome (MIS) is labelled as MIS-C when it develops in children following a COVID-19 infection. In rare cases, it can develop in adults (MIS-A). Various published case reports have noted that it can also develop after vaccination (MIS-V) without any evidence of a prior COVID-19 infection. Onset of MIS-V can be weeks after initial infection.

Symptoms of MIS-C/A/V are similar to Kawasaki disease.

Published case reports on MIS-V

  • Nune et al. - 2 days to onset, 44 year old female. "we highlight the first reported MIS-V case after the SARS-CoV-2 vaccine"
  • Choi et al. - 10 days to onset, 22 year old female. "Ten days after receiving the first dose of coronavirus disease vaccine, a 22-year-old woman in South Korea experienced myocarditis, myopathy, pericarditis, and gastroenteritis; rash subsequently developed."
  • Grome et al. - 22 days to onset, male healthcare worker in his 30s. "a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination."
  • Salzman et al. - Onset not clear, 20 year old female, vaccinated 15 days before hospital admission.
  • Buchhorn et al. - Onset 10 weeks after vaccination, 18 year old male.

Selected VAERS case reports

  • 2006451 - 12 days to onset, 6 year old female diagnosed with Kawasaki disease.
  • 1998916 - 27 days to onset, 9 year old female diagnosed with Kawasaki disease. "5 days after covid-19 pfizer vaccine was given she developed a fever with a mild rash on her extremities. [...] Rash progressed to what appeared to be erythema multiforme, she had conjunctivitis as well as persistent fevers. Ended up being sent to ED on 12/31/21 for leukocytosis and thrombocytopenia [...]"
  • 2006451 - 12 days to onset, 6 year old female who was diagnosed with Kawasaki disease. Vaccinated on 12-11-2021, developed rash 12/23.
  • 2175151 - 2 days to onset, 15 year old male diagnosed with Kawasaki's disease.
  • 2194347 - 69 days to onset, 5 year old female diagnosed with MIS-C. History of Kawasaki disease X2, 2018/2020.
  • 2226084 - Kawasaki disease following COVID, vaccination was 266 days ago.
  • 2271220 - 54 days to onset, 10 year old male with "MIS-C vs Kawasaki".
  • 2271233 - 39 days to onset, 10 year old male. "Constellation of symptoms is concerning for Kawasaki versus MIS-C."
  • 2137230 - 43 days to onset, 7 year old male being treated for MIS-C.