Vaccine differences - Revision history

User123: /* Adult versus pediatric formulation */

2023-09-30T22:46:11Z

Adult versus pediatric formulation

← Older revision		Revision as of 22:46, 30 September 2023
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	The FDA has [https://www.fda.gov/media/153714/download a fact sheet] on the EUA-approved Pfizer vaccine for 5-11 year olds.		The FDA has [https://www.fda.gov/media/153714/download a fact sheet] on the EUA-approved Pfizer vaccine for 5-11 year olds.

			An updated guidance on pediatric COVID vaccines from the AAP can be found here: https://downloads.aap.org/AAP/PDF/COVID%20Vaccine%20Dosing_Quick%20Reference.pdf

User123: /* Spike protein */

2022-06-17T22:08:49Z

Spike protein

← Older revision		Revision as of 22:08, 17 June 2022
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	In theory, a modified furin cleavage site could prevent the spike protein from being split into S1 and S2. Full-length spike protein has different biological characteristics than the split subunits. However, in practice, vaccine injuries are occurring with all of the major vaccines being used (Sinovac, JnJ, AstraZeneca, Moderna, Pfizer). This may be due to all of the spike proteins ultimately being split and/or creating S1 subunits that are responsible for vaccine injury. See the [[Etiology\|etiology]] page for a discussion on the various theories regarding spike protein toxicity.		In theory, a modified furin cleavage site could prevent the spike protein from being split into S1 and S2. Full-length spike protein has different biological characteristics than the split subunits. However, in practice, vaccine injuries are occurring with all of the major vaccines being used (Sinovac, JnJ, AstraZeneca, Moderna, Pfizer). This may be due to all of the spike proteins ultimately being split and/or creating S1 subunits that are responsible for vaccine injury. See the [[Etiology\|etiology]] page for a discussion on the various theories regarding spike protein toxicity.

	~~Some vaccines like Pfizer only contain the S1 spike protein (without S2), while other vaccines use "full length" spike protein that contains both subunits.~~

	== Adult versus pediatric formulation ==		== Adult versus pediatric formulation ==

User123: /* Dosage */

2022-02-21T15:17:34Z

Dosage

← Older revision		Revision as of 15:17, 21 February 2022
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	*'''Adult dose and ages 12+''': 30 micrograms		*'''Adult dose and ages 12+''': 30 micrograms
	*'''Adult booster''': 30 micrograms		*'''Adult booster''': 30 micrograms
	*'''Ages 5-11: 10 micrograms''': 10 micrograms (source: [~~FDA~~ https://www.fda.gov/news-events/press-announcements/fda-authorizes-pfizer-biontech-covid-19-vaccine-emergency-use-children-5-through-11-years-age])		*'''Ages 5-11: 10 micrograms''': 10 micrograms (source: [https://www.fda.gov/news-events/press-announcements/fda-authorizes-pfizer-biontech-covid-19-vaccine-emergency-use-children-5-through-11-years-age FDA])

	== Spike protein ==		== Spike protein ==

User123: /* Adult versus pediatric formulation */

2022-01-30T17:15:41Z

Adult versus pediatric formulation

← Older revision		Revision as of 17:15, 30 January 2022
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	Due to the differences between the adult and pediatric formulations, the CDC recommends against using the adult/adolescent formulation in 5-11 year olds.		Due to the differences between the adult and pediatric formulations, the CDC recommends against using the adult/adolescent formulation in 5-11 year olds.

			The FDA has [https://www.fda.gov/media/153714/download a fact sheet] on the EUA-approved Pfizer vaccine for 5-11 year olds.

User123: /* Adult versus pediatric formulation */

2022-01-30T17:13:30Z

Adult versus pediatric formulation

← Older revision		Revision as of 17:13, 30 January 2022
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	A single page cheat sheet by the CDC summarizes differences between adult and pediatric formulations: https://www.cdc.gov/vaccines/covid-19/downloads/Pfizer-Pediatric-Reference-Planning.pdf		A single page cheat sheet by the CDC summarizes differences between adult and pediatric formulations: https://www.cdc.gov/vaccines/covid-19/downloads/Pfizer-Pediatric-Reference-Planning.pdf

			[[File:CDC adult versus pediatric formulation.png]]

			Due to the differences between the adult and pediatric formulations, the CDC recommends against using the adult/adolescent formulation in 5-11 year olds.

User123 at 17:11, 30 January 2022

2022-01-30T17:11:33Z

← Older revision		Revision as of 17:11, 30 January 2022
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	Some vaccines like Pfizer only contain the S1 spike protein (without S2), while other vaccines use "full length" spike protein that contains both subunits.		Some vaccines like Pfizer only contain the S1 spike protein (without S2), while other vaccines use "full length" spike protein that contains both subunits.

			== Adult versus pediatric formulation ==

			A single page cheat sheet by the CDC summarizes differences between adult and pediatric formulations: https://www.cdc.gov/vaccines/covid-19/downloads/Pfizer-Pediatric-Reference-Planning.pdf

User123: /* Spike protein */

2022-01-30T17:01:03Z

Spike protein

← Older revision		Revision as of 17:01, 30 January 2022
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	In theory, a modified furin cleavage site could prevent the spike protein from being split into S1 and S2. Full-length spike protein has different biological characteristics than the split subunits. However, in practice, vaccine injuries are occurring with all of the major vaccines being used (Sinovac, JnJ, AstraZeneca, Moderna, Pfizer). This may be due to all of the spike proteins ultimately being split and/or creating S1 subunits that are responsible for vaccine injury. See the [[Etiology\|etiology]] page for a discussion on the various theories regarding spike protein toxicity.		In theory, a modified furin cleavage site could prevent the spike protein from being split into S1 and S2. Full-length spike protein has different biological characteristics than the split subunits. However, in practice, vaccine injuries are occurring with all of the major vaccines being used (Sinovac, JnJ, AstraZeneca, Moderna, Pfizer). This may be due to all of the spike proteins ultimately being split and/or creating S1 subunits that are responsible for vaccine injury. See the [[Etiology\|etiology]] page for a discussion on the various theories regarding spike protein toxicity.

	Some vaccines like Pfizer only contain the S1 spike protein (without S2), while other vaccines use "full length" spike protein that contains both ~~parts~~.		Some vaccines like Pfizer only contain the S1 spike protein (without S2), while other vaccines use "full length" spike protein that contains both subunits.

User123: /* Spike protein */

2022-01-30T16:58:35Z

Spike protein

← Older revision		Revision as of 16:58, 30 January 2022
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	== Spike protein ==		== Spike protein ==

	~~The~~ vaccines all have differences in the spike protein sequence. The spike protein is made up of the S1 and S2 subunits joined at a furin cleavage site, where furin enzymes in the human host can cut the protein into two and enable the entry of the virus into human cells.		COVID vaccines all have differences in the spike protein sequence. The spike protein is made up of the S1 and S2 subunits joined at a furin cleavage site, where furin enzymes in the human host can cut the protein into two and enable the entry of the virus into human cells.

	Two vaccines, Johnson&Johnson/Janssen and Novavax, use a modified furin cleavage site so that the spike protein is resistant against splitting/cleavage by furins. [https://www.nejm.org/doi/full/10.1056/NEJMc2106075 A letter from a Janssen representative] briefly describes how the vaccine's modified furin cleavage site may cause it to be biologically different than a competing adenovirus-vector vaccine (Astrazeneca ChAdOx1 nCoV-19). [https://doi.org/10.1126/science.abe1502 A scientific paper] published in ''Science'' discusses why the furin cleavage site was modified to increase vaccine effectiveness.		Two vaccines, Johnson&Johnson/Janssen and Novavax, use a modified furin cleavage site so that the spike protein is resistant against splitting/cleavage by furins. [https://www.nejm.org/doi/full/10.1056/NEJMc2106075 A letter from a Janssen representative] briefly describes how the vaccine's modified furin cleavage site may cause it to be biologically different than a competing adenovirus-vector vaccine (Astrazeneca ChAdOx1 nCoV-19). [https://doi.org/10.1126/science.abe1502 A scientific paper] published in ''Science'' discusses why the furin cleavage site was modified to increase vaccine effectiveness.

User123: need to add information on dose-dependent effects

2022-01-30T16:55:09Z

need to add information on dose-dependent effects

New page

== Dosage ==

Moderna
*'''Adult dose''': 100 micrograms
*'''Booster''': 50 micrograms (source: the [https://www.fda.gov/media/144637/download FDA] states 0.25mL volume instead of 0.5mL)

Pfizer
*'''Adult dose and ages 12+''': 30 micrograms
*'''Adult booster''': 30 micrograms
*'''Ages 5-11: 10 micrograms''': 10 micrograms (source: [FDA https://www.fda.gov/news-events/press-announcements/fda-authorizes-pfizer-biontech-covid-19-vaccine-emergency-use-children-5-through-11-years-age])

== Spike protein ==

The vaccines all have differences in the spike protein sequence. The spike protein is made up of the S1 and S2 subunits joined at a furin cleavage site, where furin enzymes in the human host can cut the protein into two and enable the entry of the virus into human cells.

Two vaccines, Johnson&Johnson/Janssen and Novavax, use a modified furin cleavage site so that the spike protein is resistant against splitting/cleavage by furins. [https://www.nejm.org/doi/full/10.1056/NEJMc2106075 A letter from a Janssen representative] briefly describes how the vaccine's modified furin cleavage site may cause it to be biologically different than a competing adenovirus-vector vaccine (Astrazeneca ChAdOx1 nCoV-19). [https://doi.org/10.1126/science.abe1502 A scientific paper] published in ''Science'' discusses why the furin cleavage site was modified to increase vaccine effectiveness.

In theory, a modified furin cleavage site could prevent the spike protein from being split into S1 and S2. Full-length spike protein has different biological characteristics than the split subunits. However, in practice, vaccine injuries are occurring with all of the major vaccines being used (Sinovac, JnJ, AstraZeneca, Moderna, Pfizer). This may be due to all of the spike proteins ultimately being split and/or creating S1 subunits that are responsible for vaccine injury. See the [[Etiology|etiology]] page for a discussion on the various theories regarding spike protein toxicity.

Some vaccines like Pfizer only contain the S1 spike protein (without S2), while other vaccines use "full length" spike protein that contains both parts.