Tilorone - Revision history

User123: /* Interchem instructions */

2023-02-08T19:17:12Z

Interchem instructions

← Older revision		Revision as of 19:17, 8 February 2023
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	== Interchem instructions ==		== Interchem instructions ==

	Instructions: https://interchem.ua/uploads/drugs/am%D1%96ksin_R_IC_%D1%96nstr_sait.pdf		Instructions: https://web.archive.org/web/20220530093137/https://interchem.ua/uploads/drugs/am%D1%96ksin_R_IC_%D1%96nstr_sait.pdf (archive.org)

	Machine translated version: https://docs.google.com/document/d/1cwvkh0GPbPsL_r1_6sb9Ie2WEMuTxLmu1z2uSyvcJwc/edit?usp=sharing		Machine translated version: https://docs.google.com/document/d/1cwvkh0GPbPsL_r1_6sb9Ie2WEMuTxLmu1z2uSyvcJwc/edit?usp=sharing

User123: /* Scientific papers */

2023-02-06T03:10:12Z

Scientific papers

← Older revision		Revision as of 03:10, 6 February 2023
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	== Scientific papers ==		== Scientific papers ==

			* ''Synergistic Suppression of the Hyperacute Form of Experimental Allergic Encephalomyelitis by Tilorone and Cycloleucine.'' - https://sci-hub.ru/10.3181/00379727-156-39956 - Tilorone and Cycloleucine had synergistic effects in delaying paralysis in rats with Experimental Allergic Encephalomyelitis (EAE), a model of autoimmunity and multiple sclerosis.
	* ''Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone'' - https://pubmed.ncbi.nlm.nih.gov/1082719 - Under selected conditions of dose and timing, tilorone delayed onset of clinical signs of encephalomyelitis, though the condition ultimately progressed to paralysis.		* ''Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone'' - https://pubmed.ncbi.nlm.nih.gov/1082719 - Under selected conditions of dose and timing, tilorone delayed onset of clinical signs of encephalomyelitis, though the condition ultimately progressed to paralysis.
	* ''Accelerated Mortality in Young NZB/NZW Mice Treated with the Interferon Inducer Tilorone Hydrochloride'' - https://deepblue.lib.umich.edu/bitstream/handle/2027.42/22849/0000410.pdf;sequence=1 - Tilorone accelerated mortality in young mice prone to developing autoimmunity as they age. However, the same effect was not seen in older mice.		* ''Accelerated Mortality in Young NZB/NZW Mice Treated with the Interferon Inducer Tilorone Hydrochloride'' - https://deepblue.lib.umich.edu/bitstream/handle/2027.42/22849/0000410.pdf;sequence=1 - Tilorone accelerated mortality in young mice prone to developing autoimmunity as they age. However, the same effect was not seen in older mice.

User123: /* Scientific papers */

2023-02-06T02:57:36Z

Scientific papers

← Older revision		Revision as of 02:57, 6 February 2023
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	* ''Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone'' - https://pubmed.ncbi.nlm.nih.gov/1082719 - Under selected conditions of dose and timing, tilorone delayed onset of clinical signs of encephalomyelitis, though the condition ultimately progressed to paralysis.		* ''Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone'' - https://pubmed.ncbi.nlm.nih.gov/1082719 - Under selected conditions of dose and timing, tilorone delayed onset of clinical signs of encephalomyelitis, though the condition ultimately progressed to paralysis.
	* ''Accelerated Mortality in Young NZB/NZW Mice Treated with the Interferon Inducer Tilorone Hydrochloride'' - https://deepblue.lib.umich.edu/bitstream/handle/2027.42/22849/0000410.pdf;sequence=1 - Tilorone accelerated mortality in young mice prone to developing autoimmunity as they age. However, the same effect was not seen in older mice.		* ''Accelerated Mortality in Young NZB/NZW Mice Treated with the Interferon Inducer Tilorone Hydrochloride'' - https://deepblue.lib.umich.edu/bitstream/handle/2027.42/22849/0000410.pdf;sequence=1 - Tilorone accelerated mortality in young mice prone to developing autoimmunity as they age. However, the same effect was not seen in older mice.
			* ''Effects of two pediatric vaccines on autoimmune diabetes in NOD female mice'' - https://sci-hub.ru/10.1016/j.toxlet.2003.09.005 - Tilorone hydrochloride and the DTaP-IPV vaccine both reduced the incidence of autoimmune diabetes. However, the study was underpowered to show statistical significance for the DTaP-IPV vaccine.

	== Side effects and safety information ==		== Side effects and safety information ==

User123: /* Scientific papers */

2023-02-06T02:48:54Z

Scientific papers

← Older revision		Revision as of 02:48, 6 February 2023
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	* ''Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone'' - https://pubmed.ncbi.nlm.nih.gov/1082719 - Under selected conditions of dose and timing, tilorone delayed onset of clinical signs of encephalomyelitis, though the condition ultimately progressed to paralysis.		* ''Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone'' - https://pubmed.ncbi.nlm.nih.gov/1082719 - Under selected conditions of dose and timing, tilorone delayed onset of clinical signs of encephalomyelitis, though the condition ultimately progressed to paralysis.
			* ''Accelerated Mortality in Young NZB/NZW Mice Treated with the Interferon Inducer Tilorone Hydrochloride'' - https://deepblue.lib.umich.edu/bitstream/handle/2027.42/22849/0000410.pdf;sequence=1 - Tilorone accelerated mortality in young mice prone to developing autoimmunity as they age. However, the same effect was not seen in older mice.

	== Side effects and safety information ==		== Side effects and safety information ==

User123: /* Tilorone usages */

2023-02-06T02:42:27Z

Tilorone usages

← Older revision		Revision as of 02:42, 6 February 2023
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	* Herpes - "Such experience exists and to determine the possibility of using the drug for the prevention of herpes you need to consult a doctor dermatovenereologist."		* Herpes - "Such experience exists and to determine the possibility of using the drug for the prevention of herpes you need to consult a doctor dermatovenereologist."
	* Potential use for SARS-CoV-2 prophylaxis and treatment		* Potential use for SARS-CoV-2 prophylaxis and treatment

			== Scientific papers ==

			* ''Necrotic myelopathy (myelomalacia) in rats with allergic encephalomyelitis treated with tilorone'' - https://pubmed.ncbi.nlm.nih.gov/1082719 - Under selected conditions of dose and timing, tilorone delayed onset of clinical signs of encephalomyelitis, though the condition ultimately progressed to paralysis.

	== Side effects and safety information ==		== Side effects and safety information ==

User123: /* Overview */

2022-09-09T04:52:20Z

Overview

← Older revision		Revision as of 04:52, 9 September 2022
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	Tilorone is water soluble, highly permeable, and is able to penetrate the blood-brain barrier. This suggests that it could access sites of the body where viruses might hide out. For a scientific review of this drug, please see the paper ''Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond'' (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7100484/).		Tilorone is water soluble, highly permeable, and is able to penetrate the blood-brain barrier. This suggests that it could access sites of the body where viruses might hide out. For a scientific review of this drug, please see the paper ''Tilorone: a Broad-Spectrum Antiviral Invented in the USA and Commercialized in Russia and beyond'' (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7100484/).

			Animal experiments suggest that tilorone can have antiviral effects without inducing interferon production (https://doi.org/10.3390/ph15050617).

	== Interferon overview ==		== Interferon overview ==

User123: /* Interferon overview */

2022-03-09T12:25:30Z

Interferon overview

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	Former Soviet bloc countries use low-cost interferon alpha-2a for cancer and a number of different infectious diseases. They also use interferon-inducing drugs such as tilorone and umifenovir (Arbidol) for many different conditions including infectious viral diseases.		Former Soviet bloc countries use low-cost interferon alpha-2a for cancer and a number of different infectious diseases. They also use interferon-inducing drugs such as tilorone and umifenovir (Arbidol) for many different conditions including infectious viral diseases.

			== Antibacterial action ==

			In vitro, tilorone has an antibacterial effect against Borrelia Burgdorferi (https://doi.org/10.3390/antibiotics4030397).

	== Tilorone usages ==		== Tilorone usages ==

User123: spellling misteaks

2022-03-09T04:19:32Z

spellling misteaks

← Older revision		Revision as of 04:19, 9 March 2022
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	'''Brand names''': Amixin IC, Amiksin IC (alternate machine-generated English translation), Lavomax		'''Brand names''': Amixin IC, Amiksin IC (alternate machine-generated English translation), Lavomax

	~~Tilerone~~ is an over-the-counter drug that is widely used in Russia and Ukraine. It is included in the list of vital and essential medicines of the Russian Federation. While invented in the USA, it is not FDA approved and is not used in the Western world.		Tilorone is an over-the-counter drug that is widely used in Russia and Ukraine. It is included in the list of vital and essential medicines of the Russian Federation. While invented in the USA, it is not FDA approved and is not used in the Western world.

	Tilorone has a track record of safe use in children and adults for ~20 years as both a prophylaxis and treatment for viral diseases. It has broad antiviral activity due to one or both of the following mechanisms:		Tilorone has a track record of safe use in children and adults for ~20 years as both a prophylaxis and treatment for viral diseases. It has broad antiviral activity due to one or both of the following mechanisms:
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	Western countries use interferon beta-1a based drugs such as Rebif (and the pegylated drug Plegridy) to treat multiple sclerosis. Pegylated interferon alpha-2a is used to hepatitis B and C. Pegylated interferon alpha-2b is used to treat melanoma (skin cancer) and was formerly used to treat hepatitis C.		Western countries use interferon beta-1a based drugs such as Rebif (and the pegylated drug Plegridy) to treat multiple sclerosis. Pegylated interferon alpha-2a is used to hepatitis B and C. Pegylated interferon alpha-2b is used to treat melanoma (skin cancer) and was formerly used to treat hepatitis C.

	Former Soviet bloc countries use low-cost interferon alpha-2a for cancer and a number of different infectious diseases. They also use interferon-inducing drugs such as ~~tilerone~~ and umifenovir (Arbidol) for many different conditions including infectious viral diseases.		Former Soviet bloc countries use low-cost interferon alpha-2a for cancer and a number of different infectious diseases. They also use interferon-inducing drugs such as tilorone and umifenovir (Arbidol) for many different conditions including infectious viral diseases.

	== ~~Tilerone~~ usages ==		== Tilorone usages ==

	According to [https://interchem.ua/en/faq#drug_26 a manufacturer's website] (Interchem):		According to [https://interchem.ua/en/faq#drug_26 a manufacturer's website] (Interchem):

User123: User123 moved page Tilerone to Tilorone

2022-03-09T04:18:57Z

User123 moved page Tilerone to Tilorone

← Older revision	Revision as of 04:18, 9 March 2022
(No difference)

User123: /* Interferon overview */

2022-02-09T12:45:14Z

Interferon overview

← Older revision		Revision as of 12:45, 9 February 2022
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	Western countries use interferon beta-1a based drugs such as Rebif (and the pegylated drug Plegridy) to treat multiple sclerosis. Pegylated interferon alpha-2a is used to hepatitis B and C. Pegylated interferon alpha-2b is used to treat melanoma (skin cancer) and was formerly used to treat hepatitis C.		Western countries use interferon beta-1a based drugs such as Rebif (and the pegylated drug Plegridy) to treat multiple sclerosis. Pegylated interferon alpha-2a is used to hepatitis B and C. Pegylated interferon alpha-2b is used to treat melanoma (skin cancer) and was formerly used to treat hepatitis C.

	Former Soviet bloc countries use low-cost interferon alpha-2a for cancer and a number of different infectious diseases. They also use interferon-inducing drugs such as tilerone and umifenovir (Arbidol).		Former Soviet bloc countries use low-cost interferon alpha-2a for cancer and a number of different infectious diseases. They also use interferon-inducing drugs such as tilerone and umifenovir (Arbidol) for many different conditions including infectious viral diseases.

	== Tilerone usages ==		== Tilerone usages ==