PSSD - Revision history

User123: /* Recovery stories */

2024-01-22T03:32:36Z

Recovery stories

← Older revision		Revision as of 03:32, 22 January 2024
Line 43:		Line 43:

	https://www.reddit.com/r/pssdhealing/		https://www.reddit.com/r/pssdhealing/

			=== Best treatments for sexual function and PSSD ===

			https://coda.io/d/Treatment-options-for-sexual-dysfunctions-and-PSSD_dBTFx_oXX31/Best-treatments-for-sexual-function-and-PSSD_suOnz#_lufhE

	== Research ==		== Research ==

User123: /* GoldenHour515 Survey */

2024-01-09T18:20:11Z

GoldenHour515 Survey

← Older revision		Revision as of 18:20, 9 January 2024
Line 98:		Line 98:
	Dropbox: https://www.dropbox.com/sh/18wiqi15udhz2e0/AABD1gHfv3Dy0sfJ6TKZlowDa?dl=0		Dropbox: https://www.dropbox.com/sh/18wiqi15udhz2e0/AABD1gHfv3Dy0sfJ6TKZlowDa?dl=0

	Deleted Reddit thread: https://www.reddit.com/r/PSSD/comments/15982kr/survey_results/		Deleted Reddit thread: https://www.reddit.com/r/PSSD/comments/15982kr/survey_results/ (It is not available through [https://web.archive.org/web/20230725131007/https://www.reddit.com/r/PSSD/comments/15982kr/survey_results/ archive.org] unfortunately.)
	* 5/135 participants stated that PSSD symptoms began after reinstatement. This suggests that (for those 5 participants) the main cause of PSSD was not an immutable characteristic such as genetics.		* 5/135 participants stated that PSSD symptoms began after reinstatement. This suggests that (for those 5 participants) the main cause of PSSD was not an immutable characteristic such as genetics.

User123: /* Baylor College */

2023-09-17T22:36:46Z

Baylor College

← Older revision		Revision as of 22:36, 17 September 2023
Line 119:		Line 119:

	=== Baylor College ===		=== Baylor College ===

			Analysis by Axolotl on the PropeciaHelp forum: https://forum.propeciahelp.com/t/differential-gene-expression-in-post-finasteride-syndrome-patients-dr-khera-baylor/49564/93

	Plain English summary: https://www.pfsnetwork.org/science/differential-gene-expression-in-post-finasteride-syndrome-patients		Plain English summary: https://www.pfsnetwork.org/science/differential-gene-expression-in-post-finasteride-syndrome-patients

User123: /* Baylor College */

2023-09-17T21:17:09Z

Baylor College

← Older revision		Revision as of 21:17, 17 September 2023
Line 124:		Line 124:
	<blockquote>This study is the first to consider and demonstrate gene expression differences in patients with PFS as a potential etiology of sexual dysfunction.</blockquote>		<blockquote>This study is the first to consider and demonstrate gene expression differences in patients with PFS as a potential etiology of sexual dysfunction.</blockquote>

	Howell and colleagues are saying that the differences in gene expression (1,446 genes significantly over-expressed and 2,318 genes significantly under-expressed) are a potential cause (etiology) of sexual dysfunction.		Howell and colleagues are saying that the differences in gene expression (1,446 genes significantly over-expressed and 2,318 genes significantly under-expressed) are a ''potential'' cause (etiology) of sexual dysfunction.

	Article (paywalled): https://doi.org/10.1016/j.jsxm.2021.05.009 \| You can request a copy of the article via ResearchGate: https://www.researchgate.net/publication/353127752_Differential_Gene_Expression_in_Post-Finasteride_Syndrome_Patients		Article (paywalled): https://doi.org/10.1016/j.jsxm.2021.05.009 \| You can request a copy of the article via ResearchGate: https://www.researchgate.net/publication/353127752_Differential_Gene_Expression_in_Post-Finasteride_Syndrome_Patients

User123: /* Research */

2023-09-17T21:06:57Z

Research

← Older revision		Revision as of 21:06, 17 September 2023
Line 117:		Line 117:

	== Research ==		== Research ==

			=== Baylor College ===

			Plain English summary: https://www.pfsnetwork.org/science/differential-gene-expression-in-post-finasteride-syndrome-patients

			<blockquote>This study is the first to consider and demonstrate gene expression differences in patients with PFS as a potential etiology of sexual dysfunction.</blockquote>

			Howell and colleagues are saying that the differences in gene expression (1,446 genes significantly over-expressed and 2,318 genes significantly under-expressed) are a potential cause (etiology) of sexual dysfunction.

			Article (paywalled): https://doi.org/10.1016/j.jsxm.2021.05.009 \| You can request a copy of the article via ResearchGate: https://www.researchgate.net/publication/353127752_Differential_Gene_Expression_in_Post-Finasteride_Syndrome_Patients

	=== PFS Network survey ===		=== PFS Network survey ===

User123: /* PFS Network survey */

2023-09-17T20:53:52Z

PFS Network survey

← Older revision		Revision as of 20:53, 17 September 2023
Line 128:		Line 128:

	https://www.pfsnetwork.org/blog/2023-updates-from-pfs-network		https://www.pfsnetwork.org/blog/2023-updates-from-pfs-network

			The mid-year update states that their team will be publishing a series of articles using data collected from their survey of PFS patients. (The survey also collected data from PSSD patients.)

	=== PropeciaHelp/PFS Network GWAS mini-study ===		=== PropeciaHelp/PFS Network GWAS mini-study ===

User123: /* Research */

2023-09-17T20:52:21Z

Research

@@ Line 117: / Line 117: @@
 == Research ==
-=== PropeciaHelp/PFD Network GWAS mini-study ===
 This study was unfortunately hindered by a very low sample size.

User123: /* PropeciaHelp/PFD Network GWAS mini-study */

2023-09-17T20:39:04Z

PropeciaHelp/PFD Network GWAS mini-study

← Older revision		Revision as of 20:39, 17 September 2023
Line 127:		Line 127:
	Nothing in the top results of the gene or pathway analyses this round sticks out as indicative of epigenetic mechanisms, known diseases, common symptoms in PFS/PAS/PSSD, steroid metabolism, AR signalling, known diseases, immunity, autoimmunity, gluten intolerance, etc…</blockquote>		Nothing in the top results of the gene or pathway analyses this round sticks out as indicative of epigenetic mechanisms, known diseases, common symptoms in PFS/PAS/PSSD, steroid metabolism, AR signalling, known diseases, immunity, autoimmunity, gluten intolerance, etc…</blockquote>
	https://forum.propeciahelp.com/t/23andme-patient-data-analysis/38786/64		https://forum.propeciahelp.com/t/23andme-patient-data-analysis/38786/64

			<blockquote>The only “hotspot” (near significance threshold) was the chr4 ~10179769-10194628 region.
			The only nearby genes were characterized as a couple pseudogenes, along with WDR1 3 and a non-coding micro-RNA, MIR3138, which appears to be located in an intron of WDR1.</blockquote>
			https://forum.propeciahelp.com/t/23andme-patient-data-analysis/38786/66

User123: /* Post Finasteride Syndrome */

2023-09-17T20:35:26Z

Post Finasteride Syndrome

← Older revision		Revision as of 20:35, 17 September 2023
Line 115:		Line 115:
	Post-Finasteride Syndrome (PFS) is a rare and devastating disease encompassing persistent physiological, sexual, and neurological health problems following exposure to a 5alpha reductase inhibitor. The condition comprises a broad and variable clinical spectrum and is responsible for relationship breakdown, disability preventing work, isolation and suicide. Herein, the administrators of the patient support website propeciahelp.com summarise the current published research into PFS, add to the understanding of the condition, and present a mechanistic hypothesis to support further scientific investigation. </blockquote>		Post-Finasteride Syndrome (PFS) is a rare and devastating disease encompassing persistent physiological, sexual, and neurological health problems following exposure to a 5alpha reductase inhibitor. The condition comprises a broad and variable clinical spectrum and is responsible for relationship breakdown, disability preventing work, isolation and suicide. Herein, the administrators of the patient support website propeciahelp.com summarise the current published research into PFS, add to the understanding of the condition, and present a mechanistic hypothesis to support further scientific investigation. </blockquote>
	https://paper.pfsnetwork.org/		https://paper.pfsnetwork.org/

			== Research ==
			=== PropeciaHelp/PFD Network GWAS mini-study ===

			This study was unfortunately hindered by a very low sample size.

			<blockquote>Unfortunately, and quite expectedly, no single SNP was observed beyond this significance threshold. The team analyzed the data with a stringent significance threshold of p<5x10^-8 so it is unlikely that there will be results that meet the stringent hurdle.

			There didn’t appear to be any greater correlation between either case group or control group and over-represented SNPs in any trait/disease featured on ImputeMe.

			Nothing in the top results of the gene or pathway analyses this round sticks out as indicative of epigenetic mechanisms, known diseases, common symptoms in PFS/PAS/PSSD, steroid metabolism, AR signalling, known diseases, immunity, autoimmunity, gluten intolerance, etc…</blockquote>
			https://forum.propeciahelp.com/t/23andme-patient-data-analysis/38786/64

User123 at 19:27, 17 September 2023

2023-09-17T19:27:35Z

← Older revision		Revision as of 19:27, 17 September 2023
Line 106:		Line 106:

	See [[Currently_recruiting_studies#PSSD_(for_those_on_SSRIs_or_suffering_post-SSRI_syndromes)_and_related_syndromes\|currently recruiting PSSD studies]].		See [[Currently_recruiting_studies#PSSD_(for_those_on_SSRIs_or_suffering_post-SSRI_syndromes)_and_related_syndromes\|currently recruiting PSSD studies]].

			=Post Finasteride Syndrome=

			Patients can experience debilitating symptoms following the discontinuation of finasteride and potentially other anti-androgen drugs: dutasteride, isotretinoin (Accutane) and serotonergic antidepressants (e.g. SSRIs).

			== Science summary ==
			<blockquote>
			Post-Finasteride Syndrome (PFS) is a rare and devastating disease encompassing persistent physiological, sexual, and neurological health problems following exposure to a 5alpha reductase inhibitor. The condition comprises a broad and variable clinical spectrum and is responsible for relationship breakdown, disability preventing work, isolation and suicide. Herein, the administrators of the patient support website propeciahelp.com summarise the current published research into PFS, add to the understanding of the condition, and present a mechanistic hypothesis to support further scientific investigation. </blockquote>
			https://paper.pfsnetwork.org/