MCAS and histamine intolerance - Revision history

User123: /* Histamine theory may be wrong */

2022-02-04T04:56:23Z

Histamine theory may be wrong

← Older revision		Revision as of 04:56, 4 February 2022
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	For those with MCAS, the same group (SIGHI) has compiled a more detailed (and complicated) food compatibility list: https://www.mastzellaktivierung.info/downloads/foodlist/21_FoodList_EN_alphabetic_withCateg.pdf		For those with MCAS, the same group (SIGHI) has compiled a more detailed (and complicated) food compatibility list: https://www.mastzellaktivierung.info/downloads/foodlist/21_FoodList_EN_alphabetic_withCateg.pdf

	== ~~Histamine theory~~ may be wrong ==		== Scientists may be wrong about how low histamine diets work ==

	Firstly, there is no scientific consensus as to what foods are low or high histamine. Table 1 in a [https://sci-hub.se/https://doi.org/10.1016/j.aller.2016.04.015 paper by Martin, Brachero, and Vilar] summarizes different claims in the scientific literature about a wide range of specific foods. You should not be surprised if online food lists contain conflicting information about low versus high histamine. In practice, patients can pick a single food list and experiment to figure out what works and what doesn't.		Firstly, there is no scientific consensus as to what foods are low or high histamine. Table 1 in a [https://sci-hub.se/https://doi.org/10.1016/j.aller.2016.04.015 paper by Martin, Brachero, and Vilar] summarizes different claims in the scientific literature about a wide range of specific foods. You should not be surprised if online food lists contain conflicting information about low versus high histamine. In practice, patients can pick a single food list and experiment to figure out what works and what doesn't.

User123: /* Histamine theory may be wrong */

2022-02-03T14:21:31Z

Histamine theory may be wrong

← Older revision		Revision as of 14:21, 3 February 2022
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	Secondly, the gut contains histamine-producing bacteria and food that they live on. For a deep dive into the scientific evidence 'supporting' histamine intolerance, see [https://doi.org/10.3390/nu13072228 the paper by Hrubisko and his colleagues] titled ''Histamine Intolerance—The More We Know the Less We Know. A Review''.		Secondly, the gut contains histamine-producing bacteria and food that they live on. For a deep dive into the scientific evidence 'supporting' histamine intolerance, see [https://doi.org/10.3390/nu13072228 the paper by Hrubisko and his colleagues] titled ''Histamine Intolerance—The More We Know the Less We Know. A Review''.

	While the theory supporting low histamine diets may be wrong, some people seem to see an improvement in their symptoms from following a low histamine diet. While we may not be certain about how it works, it is a path of experimentation that may improve symptoms. Patients may discover that their food intolerances do not necessarily perfectly line up with the theoretical content of histamines, histamine liberators, DAO, etc.		While the theory supporting low histamine diets may be wrong, some people seem to see an improvement in their symptoms from following a low histamine diet. While we may not be certain about how it works, it is a path of experimentation that may improve symptoms. Patients may discover that their food intolerances do not necessarily perfectly line up with the theoretical content of histamines, histamine liberators, DAO (enzymes that break down histamines), etc. It is also possible for patients to have non-histamine food intolerances such as gluten sensitivity (including the non-celiac version of gluten sensitivity that returns a negative celiac biopsy test).

	== Medications ==		== Medications ==

User123: /* Histamine theory may be wrong */

2022-02-03T14:16:57Z

Histamine theory may be wrong

← Older revision		Revision as of 14:16, 3 February 2022
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	Secondly, the gut contains histamine-producing bacteria and food that they live on. For a deep dive into the scientific evidence 'supporting' histamine intolerance, see [https://doi.org/10.3390/nu13072228 the paper by Hrubisko and his colleagues] titled ''Histamine Intolerance—The More We Know the Less We Know. A Review''.		Secondly, the gut contains histamine-producing bacteria and food that they live on. For a deep dive into the scientific evidence 'supporting' histamine intolerance, see [https://doi.org/10.3390/nu13072228 the paper by Hrubisko and his colleagues] titled ''Histamine Intolerance—The More We Know the Less We Know. A Review''.

	While the theory supporting low histamine diets may be wrong, some people seem to see an improvement in their symptoms from following a low histamine diet. While we may not be certain about how it works, it is a path of experimentation that may improve symptoms.		While the theory supporting low histamine diets may be wrong, some people seem to see an improvement in their symptoms from following a low histamine diet. While we may not be certain about how it works, it is a path of experimentation that may improve symptoms. Patients may discover that their food intolerances do not necessarily perfectly line up with the theoretical content of histamines, histamine liberators, DAO, etc.

	== Medications ==		== Medications ==

User123: /* MCAS specialists */

2022-02-03T01:35:14Z

MCAS specialists

← Older revision		Revision as of 01:35, 3 February 2022
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	MCAS specialists can also perform various medical tests to diagnose MCAS. However:		MCAS specialists can also perform various medical tests to diagnose MCAS. However:
	* The tests often return false positives, e.g. when the patient isn't in the middle of a flare.		* The tests often return false positives, e.g. when the patient isn't in the middle of a flare.
	* ~~Medical~~ tests do not predict whether or not a particular treatment will alleviate symptoms.		* The tests for MCAS do not predict whether or not a particular treatment will alleviate symptoms.

	== Guides and resources for HIT and MCAS ==		== Guides and resources for HIT and MCAS ==

User123: /* Histamine theory may be wrong */

2022-02-03T01:34:29Z

Histamine theory may be wrong

← Older revision		Revision as of 01:34, 3 February 2022
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	== Histamine theory may be wrong ==		== Histamine theory may be wrong ==

	Firstly, there is no scientific consensus as to what foods are low or high histamine. Table 1 in a [https://sci-hub.se/https://doi.org/10.1016/j.aller.2016.04.015 paper by Martin, Brachero, and Vilar] ~~summarize~~ the ~~different opinions on~~ a wide range of specific foods. You should not be surprised if online food lists contain conflicting information about low versus high histamine. In practice, patients can pick a single food list and experiment to figure out what works and what doesn't.		Firstly, there is no scientific consensus as to what foods are low or high histamine. Table 1 in a [https://sci-hub.se/https://doi.org/10.1016/j.aller.2016.04.015 paper by Martin, Brachero, and Vilar] summarizes different claims in the scientific literature about a wide range of specific foods. You should not be surprised if online food lists contain conflicting information about low versus high histamine. In practice, patients can pick a single food list and experiment to figure out what works and what doesn't.

	Secondly, the gut contains histamine-producing bacteria and food that they live on. For a deep dive into the scientific evidence 'supporting' histamine intolerance, see [https://doi.org/10.3390/nu13072228 the paper by Hrubisko and his colleagues] titled ''Histamine Intolerance—The More We Know the Less We Know. A Review''.		Secondly, the gut contains histamine-producing bacteria and food that they live on. For a deep dive into the scientific evidence 'supporting' histamine intolerance, see [https://doi.org/10.3390/nu13072228 the paper by Hrubisko and his colleagues] titled ''Histamine Intolerance—The More We Know the Less We Know. A Review''.

	While the theory supporting low histamine diets may be wrong, some people seem to see an improvement in their symptoms from following a low histamine diet. It may be a path of experimentation that ~~yields results, even if the scientific validity of a low histamine diet is uncertain~~.		While the theory supporting low histamine diets may be wrong, some people seem to see an improvement in their symptoms from following a low histamine diet. While we may not be certain about how it works, it is a path of experimentation that may improve symptoms.

	== Medications ==		== Medications ==

User123 at 14:05, 2 February 2022

2022-02-02T14:05:07Z

← Older revision		Revision as of 14:05, 2 February 2022
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	MCAS stands for mast cell activation syndrome. Some MCAS specialists believe that overactive mast cells are responsible for a wide range of health problems; they may even [[Etiology#Mast_cell_activation_syndrome_(MCAS)\|be responsible for long COVID]]. While MCAS may be difficult to diagnose through medical testing, some patients are able to reduce their symptoms through a trial and error process of trying different foods and medications.		MCAS stands for mast cell activation syndrome. Some MCAS specialists believe that overactive mast cells are responsible for a wide range of health problems; they may even [[Etiology#Mast_cell_activation_syndrome_(MCAS)\|be responsible for long COVID]]. While MCAS may be difficult to diagnose through medical testing, some patients are able to reduce their symptoms through a trial and error process of trying different foods and medications.

	MCAS and histamine intolerance are related because they have overlapping symptoms and treatments.		Histamine is a chemical normally produced by your body that is released into the bloodstream when your immune system is defending against a potential allergen. The theory is that some people are prone to accumulating too much histamine in their body, which can lead to toxic effects. MCAS and histamine intolerance are related because they have overlapping symptoms and treatments.

	Some long haulers report that a low histamine diet and/or MCAS treatments improve their symptoms.		Some long haulers report that a low histamine diet and/or MCAS treatments improve their symptoms.
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	For those with MCAS, the same group (SIGHI) has compiled a more detailed (and complicated) food compatibility list: https://www.mastzellaktivierung.info/downloads/foodlist/21_FoodList_EN_alphabetic_withCateg.pdf		For those with MCAS, the same group (SIGHI) has compiled a more detailed (and complicated) food compatibility list: https://www.mastzellaktivierung.info/downloads/foodlist/21_FoodList_EN_alphabetic_withCateg.pdf

			== Histamine theory may be wrong ==

			Firstly, there is no scientific consensus as to what foods are low or high histamine. Table 1 in a [https://sci-hub.se/https://doi.org/10.1016/j.aller.2016.04.015 paper by Martin, Brachero, and Vilar] summarize the different opinions on a wide range of specific foods. You should not be surprised if online food lists contain conflicting information about low versus high histamine. In practice, patients can pick a single food list and experiment to figure out what works and what doesn't.

			Secondly, the gut contains histamine-producing bacteria and food that they live on. For a deep dive into the scientific evidence 'supporting' histamine intolerance, see [https://doi.org/10.3390/nu13072228 the paper by Hrubisko and his colleagues] titled ''Histamine Intolerance—The More We Know the Less We Know. A Review''.

			While the theory supporting low histamine diets may be wrong, some people seem to see an improvement in their symptoms from following a low histamine diet. It may be a path of experimentation that yields results, even if the scientific validity of a low histamine diet is uncertain.

	== Medications ==		== Medications ==

User123: almost done first version of this page

2022-02-02T13:26:17Z

almost done first version of this page

← Older revision		Revision as of 13:26, 2 February 2022
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	MCAS stands for mast cell activation syndrome. Some MCAS specialists believe that overactive mast cells are responsible for a wide range of health problems; they may even [[Etiology#Mast_cell_activation_syndrome_(MCAS)\|be responsible for long COVID]]. While MCAS may be difficult to diagnose through medical testing, some patients are able to reduce their symptoms through a trial and error process of trying different foods and medications.		MCAS stands for mast cell activation syndrome. Some MCAS specialists believe that overactive mast cells are responsible for a wide range of health problems; they may even [[Etiology#Mast_cell_activation_syndrome_(MCAS)\|be responsible for long COVID]]. While MCAS may be difficult to diagnose through medical testing, some patients are able to reduce their symptoms through a trial and error process of trying different foods and medications.

			MCAS and histamine intolerance are related because they have overlapping symptoms and treatments.

	Some long haulers report that a low histamine diet and/or MCAS treatments improve their symptoms.		Some long haulers report that a low histamine diet and/or MCAS treatments improve their symptoms.
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	Some patients find that not all H1/H2 blockers improve their symptoms so trial and error is needed to find a blocker that they respond to.		Some patients find that not all H1/H2 blockers improve their symptoms so trial and error is needed to find a blocker that they respond to.

	DAO enzymes taken 30-60 minutes before a meal may be useful as ~~the~~ DAO enzymes break down histamines. They may come in handy for social situations which involve eating foods that might have histamines in it.		DAO enzymes taken 30-60 minutes before a meal may be useful as DAO enzymes break down histamines. They may come in handy for social situations which involve eating foods that might have histamines in it.

	Many other drugs (mostly prescription) are used to treat MCAS. Examples of such drugs include:		Many other drugs (mostly prescription) are used to treat MCAS. Examples of such drugs include:

User123 at 01:22, 2 February 2022

2022-02-02T01:22:50Z

← Older revision		Revision as of 01:22, 2 February 2022
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			[[File:Histamine symptoms.png\|thumb\|Summary of histamine-mediated symptoms from https://doi.org/10.1093/ajcn/85.5.1185]]

	MCAS stands for mast cell activation syndrome. Some MCAS specialists believe that overactive mast cells are responsible for a wide range of health problems; they may even [[Etiology#Mast_cell_activation_syndrome_(MCAS)\|be responsible for long COVID]]. While MCAS may be difficult to diagnose through medical testing, some patients are able to reduce their symptoms through a trial and error process of trying different foods and medications.		MCAS stands for mast cell activation syndrome. Some MCAS specialists believe that overactive mast cells are responsible for a wide range of health problems; they may even [[Etiology#Mast_cell_activation_syndrome_(MCAS)\|be responsible for long COVID]]. While MCAS may be difficult to diagnose through medical testing, some patients are able to reduce their symptoms through a trial and error process of trying different foods and medications.

User123 at 23:07, 1 February 2022

2022-02-01T23:07:58Z

← Older revision		Revision as of 23:07, 1 February 2022
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	MCAS stands for mast cell activation syndrome. Some MCAS specialists believe that overactive mast cells are responsible for a wide range of health problems. While MCAS may be difficult to diagnose through medical testing, some patients are able to reduce their symptoms through a trial and error process of trying different foods and medications.		MCAS stands for mast cell activation syndrome. Some MCAS specialists believe that overactive mast cells are responsible for a wide range of health problems; they may even [[Etiology#Mast_cell_activation_syndrome_(MCAS)\|be responsible for long COVID]]. While MCAS may be difficult to diagnose through medical testing, some patients are able to reduce their symptoms through a trial and error process of trying different foods and medications.

	Some long haulers report that a low histamine diet and/or MCAS treatments improve their symptoms.		Some long haulers report that a low histamine diet and/or MCAS treatments improve their symptoms.

User123: /* Medications */

2022-01-31T23:19:37Z

Medications

← Older revision		Revision as of 23:19, 31 January 2022
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	Over-the-counter antihistamines include:		Over-the-counter antihistamines include:
	* Loratadine (Claritin), fexofenadine (Allegra), cetirizine (Zyrtec, Benadryl Allergy One a Day Relief 🇬🇧), levocetirizine (Xyzal) and acrivastine (Benadryl Allergy Relief 🇬🇧) are H1 blockers that are sold over-the-counter in most countries. Some of the drugs require a prescription in some countries, e.g. fexofenadine in the UK.		* Loratadine (Claritin), fexofenadine (Allegra), cetirizine (Zyrtec, Benadryl Allergy One a Day Relief 🇬🇧), levocetirizine (Xyzal) and acrivastine (Benadryl Allergy Relief 🇬🇧) are H1 blockers that are sold over-the-counter in most countries. Some of the drugs require a prescription in some countries, e.g. fexofenadine in the UK.
	* Famotidine (Pepcid) is a H2 blocker ~~that is sold over-the-counter.~~		* Famotidine (Pepcid) is a H2 blocker

	Some patients find that not all H1/H2 blockers improve their symptoms so trial and error is needed to find a blocker that they respond to.		Some patients find that not all H1/H2 blockers improve their symptoms so trial and error is needed to find a blocker that they respond to.