Talk:Etiology

MCAS references

Theoharides

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8250989/ - Long‐COVID syndrome‐associated brain fog and chemofog: Luteolin to the rescue https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7267424/ - COVID‐19, pulmonary mast cells, cytokine storms, and beneficial actions of luteolin https://pubmed.ncbi.nlm.nih.gov/33023287/ - COVID-19 and Multisystem Inflammatory Syndrome, or is it Mast Cell Activation Syndrome? https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7644430/ - Potential association of mast cells with coronavirus disease 2019

other

https://pubmed.ncbi.nlm.nih.gov/32920235/ - Afrin et al. Covid-19 hyperinflammation and post-Covid-19 illness may be rooted in mast cell activation syndrome

archive

Prion / bart classen https://scivisionpub.com/pdfs/covid19-rna-based-vaccines-and-the-risk-of-prion-disease-1503.pdf

Exosomes containing microRNAs

Mishra and Banerjea performed in vitro experiments which suggest that mRNA vaccines lead to the creation of exosomes containing microRNAs such as miR-148a and miR-590. These microRNAs are internalized by human microglia (immune cells in the central nervous system) and suppress target gene expression of USP33 (Ubiquitin Specific peptidase 33) and downstream IRF9 levels", ultimately resulting in "CNS damage through hyperactivation of human microglia". Because their experiments were performed on cells in vitro, their results likely would not be replicated in humans with a functional adaptive immune system.

Röltgen et al. claim that vaccine spike antigen and mRNA persist for weeks in lymph node germinal centers.

References:

• SARS-CoV-2 Spike Targets USP33-IRF9 Axis via Exosomal miR-148a to Activate Human Microglia https://dx.doi.org/10.3389%2Ffimmu.2021.656700
• Immune imprinting, breadth of variant recognition and germinal center response in human SARS-CoV-2 infection and vaccination https://doi.org/10.1016/j.cell.2022.01.018